We use cortisone injections for arthritis and tendonitis. Commonly asked questions include how long does it take for a cortisone shot to work. In this blog, we answer the most common questions about cortisone injections. 

Why does a cortisone shot work? 

Cortisone is also known as a corticosteroid. It is a drug that reduces inflammation.

Diseases of joints and tendons produce inflammation. When inflammation makes joints and tendons painful and activities difficult, we use a cortisone shot to help with treatment. However, you should understand that the effect of a cortisone shot is only temporary. Generally, a cortisone shot does not cure arthritis or tendonitis, but reducing pain can improve the impact of rehab.

Do steroid shots hurt? 

Usually, you will feel some discomfort during a steroid shot. However, as a local anaesthetic is used, most people tolerate these injections well. 

Also, ultrasound reduces pain by ensuring the cortisone goes directly to the target. We direct the cortisone into the right area, meaning the time it takes for an injection is much less. 

You need to tell your doctor about your medical history

Overall, cortisone shots are very safe. However, some medical diseases, such as diabetes, cancer, or HIV, can interact with cortisone. Also, if you take a blood thinner such as Warfarin, you may need to stop the medication briefly. Warfarin and cortisone injections could increase your risk of bleeding.

How long does it take for a cortisone shot to work?

People often ask this question: How long does a cortisone shot take to work? Knowing this fact is essential when you have an upcoming event, such as a marathon or a sports final. Choosing the best time for a cortisone shot could be the difference between success and failure.

Generally, a cortisone shot takes 1-2 weeks to start working. We often say you should leave for the cortisone shot to work about a week before an event. Also, you must be aware that cortisone can cause a flare of pain in the first few days. Therefore, you must rest for a few days after the cortisone shot to prevent the flare from worsening.

How long does a cortisone injection last?

The effect of a cortisone shot can last anywhere from 6 weeks to 6 months. As cortisone reduces inflammation, it can make you feel great. However, this effect is temporary, as cortisone does not cure the disease. Nevertheless, this window of pain relief can help with rehab. In addition, combining a cortisone shot with exercise can provide more significant pain relief. Lifestyle factors such as weight loss, muscle strength, and footwear can also help.

How long does cortisone stay in your system?

Generally, any cortisone injection will affect the body. However, this effect is small and lasts only 3-4 weeks.

My cortisone shot didn’t work – what does this mean? 

Failure of a cortisone shot may occur for several reasons. Firstly, the correct diagnosis is essential. A cortisone shot will not have a positive effect if the wrong site is injected. Secondly, correct needle placement is critical. Using ultrasound improves the accuracy and, therefore, the effectiveness of a cortisone shot. Finally, the failure of proper rehabilitation after a cortisone shot is another important reason.

What are the side effects of a cortisone shot? 

Generally, cortisone shots are very safe if used for the right reasons.

However, like any medical treatment, there are always side effects. These potential side effects include:

  • Allergic reaction (rare)
  • Infection (1/100000)
  • Skin thinning and discolouration. We can reduce this side effect by using ultrasound.
  • Bleeding into joints.
  • Cortisone flare causes increased pain for the first few days (see below).

Pain after cortisone injection: What does it mean? 

Pain after a cortisone injection is generally the most common side effect. We call this reaction a cortisone flare.

A cortisone flare usually starts after 6 hours and lasts up to 5 days. One study suggested that it can last up to 4 days.

If you develop a cortisone flare, we recommend rest from activities, including sports, until the pain settles. However, you can continue exercising that doesn’t make your pain worse. In addition, try regular ice packs for 10 minutes every 6 hours and regular ibuprofen 400mg thrice a day.

Can I take ibuprofen after a cortisone shot? 

Yes. Ibuprofen or other anti-inflammatories will help settle a cortisone flare. Ibuprofen is a safe and effective way to resolve a flare after an injection. We suggest immediate treatment with regular ice (every 3 hours) and ibuprofen to prevent flaring.

How many cortisone shots can you have?

There are no hard and fast rules on the maximal number of cortisone injections. However, there are concerns about repeated injections into one area. This is because the effect of cortisone varies among patients. Generally, if the first shot doesn’t work, we may inject the same area again after 6-8 weeks. However, if a second shot doesn’t work, we don’t recommend a third shot. Can you get two cortisone shots at the same time?

Can you get two cortisone shots at the same time? 

Yes, but we must be cautious regarding more than one cortisone simultaneously.

First, as a cortisone shot can cause a significant flare, we avoid injecting the same body part on both sides, e.g., knees or hips. Generally, we suggest injecting one side at a time, separated by at least a week. So, if you develop a flare, you can still function by using the unaffected side.

Second, two cortisone shots simultaneously mean a more significant dose of cortisone. In older patients, a hefty dose of cortisone may cause side effects such as tiredness.

ultrasound-guided wrist injection

Can you drive home after a cortisone injection?   

Firstly, you should wait at least 15 minutes after a cortisone shot before going home. Sometimes, injections make you feel dizzy or lightheaded. This effect is short-lived and settles after a few minutes.

Many insurance policies have strict rules on driving after a medical procedure. They require you to be able to apply an emergency brake when driving. So, as a general rule, we advise against driving after a cortisone injection into the hip, knee, or foot. However, cortisone injections into the shoulder, elbow, or hand can stop you from driving properly. We suggest a friend or family member drive you home, or you take the tube or a Taxi.

Is a cortisone shot safe during pregnancy or breastfeeding?  

Cortisone is generally safe during pregnancy. However, we don’t like to inject it into pregnant women unless necessary. We also suggest that pregnant women speak to their obstetrician. Breastfeeding is not an issue, as the amount of cortisone absorbed in breast milk from one injection is very small.

Other common questions about a cortisone shot:

Can cortisone shots affect your periods? And how long do steroid injections affect the menstrual cycle?

Yes, and it’s more common than we think. Cortisone can temporarily stop your periods or cause bleeding or spotting for a few weeks. However, a change in your periods can be due to another cause.

A recent study found that a steroid injection disturbed the menstrual cycle in just over 50% of women. Both reduced and increased bleeding were reported. The effect usually lasts for one cycle only. Also, those women on the oral contraceptive pill had less menstrual cycle variability.

Do cortisone shots cause weight gain?

While cortisone can increase appetite and weight, this effect is only seen when taking high doses of tablets for many weeks. One to two cortisone shots over a few months are usually unlikely to cause a significant change in appetite or weight.

Hiccups and cortisone injections: Is there a link? 

Yes. Cortisone injections can cause hiccups. However, we don’t know exactly why. The good news is that hiccups usually settle after one to two days.

How long after a cortisone shot can I drink alcohol? 

Drinking alcohol will increase blood flow and bleeding after a cortisone injection. Therefore, we suggest you avoid alcohol for at least a few days after a cortisone shot.

Flushed cheeks after a cortisone injection: Is it common? 

Yes. This effect of facial flushing is more common in women, primarily if we use triamcinolone. Fortunately, it lasts only 1-2 days and is readily treated with an antihistamine drug. 

What causes facial flushing after a cortisone injection?

We don’t know the answer, but we think cortisone causes a histamine-like reaction, similar to a mild allergic reaction. Blood vessels in the face dilate, causing a flush. Thankfully, this reaction is self-limiting and lasts for a day or two.

Can a cortisone shot cause insomnia? 

Yes, but it’s not common. Like flushed cheeks, cortisone can cause insomnia or sleeplessness, which is transient and lasts 1-2 days.

Can you get a cortisone injection after a knee replacement? 

We generally do not recommend having a cortisone injection after a knee replacement. Injecting an artificial joint increases the risk of infection.

Do cortisone injections damage joints?

A recent study suggested that frequent cortisone injections harm knee cartilage. However, the people in this study had eight injections over two years. Generally, 1-2 cortisone injections are safe and effective in reducing pain and swelling in knee arthritis. However, repeated injections into one joint can increase the risk of damage.

Can you have cortisone injections while on blood thinners? 

We used to think that taking blood thinners such as Warfarin increased the risk of bleeding after injections into large joints such as the hip or shoulder. However, a recent study showed that bleeding is not increased, irrespective of the dose of blood thinner. So, we don’t think you need to stop or reduce the amount of blood thinner before performing a joint injection.

Are cortisone shots better under ultrasound?

Yes. There is good evidence that ultrasound guidance improves the accuracy and effect of a cortisone shot. If you are thinking about a cortisone shot, you should see a doctor with experience in ultrasound-guided injections. Unfortunately, not all practitioners performing injections are qualified. See this blog for the top 4 questions before an ultrasound-guided injection. 

Glaucoma and cortisone shots: What should you do? 

We know that cortisone can increase pressure in your eye, leading to glaucoma. However, we think that this risk is minimal with a cortisone shot. Generally, if you have stable glaucoma, one cortisone shot is unlikely to cause problems. However, if in doubt, you should check with your eye specialist. However, acute vision loss is a rare side effect of a cortisone shot. We think cortisone increases the risk of a rare condition called central serous retinopathy. You must seek medical attention immediately if you develop sudden vision loss in the eye after a cortisone shot.

Can I get a cortisone shot while breastfeeding?

Yes. The amount of cortisone absorbed by your body after a local cortisone shot is small. Only a tiny fraction of systemic cortisone is excreted into breast milk. So, having a cortisone shot while breastfeeding is entirely safe.

Can a cortisone shot help bursitis? 

Yes. Generally, bursitis forms secondary to tendonitis. For example, trochanteric bursitis in the hip is often secondary to hip tendonitis. A cortisone shot is helpful to reduce pain from bursitis, but it should always be combined with physical therapy to strengthen the hip tendons. 

What happens when a cortisone shot hits a nerve? 

If cortisone is injected directly into the nerve, it will cause intense burning pain, pins and needles, or numbness. This effect is usually temporary and settles within minutes. However, if the nerve is damaged, these symptoms can last from days to a few weeks. Generally, nerve damage does settle. 

Do cortisone shots make you tired? 

Having one cortisone injection is unlikely to make you tired. However, having two or three cortisone shots at once can temporarily shut down cortisone production by the adrenal gland, leading to a condition called Addison’s disease. This condition can lead to reduced energy and extreme fatigue, lasting a few weeks or longer. The risk of iatrogenic Addison’s disease is increased when using the more potent triamcinolone. 

Are there alternatives to cortisone injections? 

Platelet-rich plasma injections - alternative to cortisone injection in shoulder

Yes. Recent studies suggest that other injections can be helpful for arthritis and tendonitis with potentially fewer side effects. 

Hyaluronic acid is a naturally occurring substance found in normal joints and tendons. Evidence suggests hyaluronic acid injections provide more extended pain relief in arthritis than cortisone. In particular, high-molecular weight hyaluronic acid, such as Durolane, shows promising results for knee arthritis and other joints. Also, we use hyaluronic acid for injections in tendinitis, such as plantaris-associated Achilles tendonitis or rotator cuff tendinitis. 

Platelet-rich plasma is obtained by spinning whole blood from a patient. The plasma contains a high concentration of platelets and growth factors and is injected into tendons and joints. There is good evidence that PRP provides long-term pain relief for knee arthritis and some tendons. You can read more about the positive effects of PRP on arthritis and tendonitis. We have also written a blog on PRP injections for knee arthritis.

Moreover, recent evidence suggests that combining hyaluronic acid and PRP might be better for knee arthritis.

Finally, a non-degradable hydrogel called Arthosamid is showing promise in reducing pain in knee arthritis in the medium to long term.

Final word from Sportdoctorlondon about how long it takes for a cortisone shot to work

A cortisone shot is a safe and effective procedure for many MSK conditions. However, cortisone injections can be harmful in the wrong hands. Generally, a cortisone shot takes about a week to start working. You should see a medical doctor with experience in ultrasound-guided injections and avoid non-medical practitioners.

More information on cortisone shot to work: